Dr Tram – World Renowned Scientist & Crila Inventor

A Compelling History of One of the World's Foremost Female Scientists: DR. NGUYEN THI NGOC TRAM

Dr Tram - Crila Inventor and world renowned scientist

THE CAREER OF PHARMACIST DR. NGUYEN THI NGOC TRAM

● Qualifications: Pharmacists, Doctor in chemistry – in 1991

● The training process
– 1972, graduating from Hanoi University of Pharmacy – Faculty of Pharmaceutical Industry
– 1984-1985, studying foreign languages in Thanh Xuan University – Hanoi 
– 1985-1986, studying foreign language in Sofia – Bulgaria.
– 1986-1990, postgraduate in Sofia University of Chemistry – Bulgaria.
– 1993-1996, senior internship at Bulgarian Academy of Sciences.

● Work experience
– 1972, technical officer in syrup workshop of Hanoi Pharmaceutical Factory.
– July 1972-1973, working at Faculty of Pharmacy-Thanh Tri hospital – Hanoi as Manager for Formulation Room, having many technical innovations in the process of work in Thanh Tri Hospital.
– 1974-1984, working at the National Committee for the Protection of Mothers and Children. 
– 1982, admitted to the Communist Party of Vietnam.
– 1984, winning the national competitive examination for postgraduate 
– 1985, traveling to Bulgaria for a postgraduate.
– 1986-1990, postgraduate at the Sofia Technical University.
– 1990, successfully defending the PhD thesis “Determination of the composition and structure of 45 compounds the essential oils of Vietnamese Cardamon” highly evaluated by the National Science Council of Bulgaria
– 1991-1993, working as assistant professor at the Sofia Technical University.
– 1994-1999, being sent to Bulgarian Academy of Sciences as a senior trainee to defend a Ph.D. thesis.
– 1990-2005, participating in the group studying Asian medicinal plants to create specific medicines for cancer and tumors. In the course of the study, Crila capsule was born and recognized by the Council of Science – the Ministry of Health. On July 21, 2005 the Drug Administration allowed Crila for nationwide circulation under Decision No. 135/QĐ-QLD with registration number VNB-3391-05 to treat BPH. On October 23, 2007 the Drug Administration announced Crila’s additional indication: the treatment of uterine fibroids under the Official Document No. 6104/QLD-DK. 
– 1999-2008, Director of The Research Development and Manufacture CRINA Center directly under National phytopharma company No.2
– 2008 till now, Director of Thien Duoc Co., Ltd.

Awards & Achievements
(The World Bank Recognizes Dr Tram)

  • August 18, 2005: National Office of Intellectual Property of Vietnam granted the registration patent and utility solution for “Medicine for BPH formulated from alkaloids extracted from Vietnamese “Royal Virgin” leaves (Crinum latifolium L.)” and its formulation methods.
  • December 4, 2007: awarded as a nationwide talented woman in the period of renovation by Vietnam Women’s Union.
  • December 19, 2007: awarded as “Excellent and creative worker” in medical branch 1st period (from 2002 to 2006) by the Ministry of Health
  • December 24, 2007: rewarded 2006 Kovalevskaia Award – the prestigious award for female scientists who have made outstanding achievements in research and practical applications in life, brought many benefits in the field of economy – society and culture.
  • February 21, 2008: National Office of Intellectual Property of Vietnam granted registration certificate of copyright for the title “Study of genetic polymorphisms of the Crinum genus (7 species), and identification of distinct genetic characteristics of “Royal Virgin” (Crinum latifolium L.) in Vietnam used as  materials for Crila capsule production”.
  • May 5, 2009: awarded for her outstanding achievements in the conservation of genes and herbal seedlings by the Minister of Health.
  • June 16, 2010: awarded the title “The woman of women” of medical branch in period of 2006-2010 by the Minister of Health
  • July 9, 2010: awarded for her outstanding achievements in patriotic emulation movement of the Vietnam Women’s Union in period of 2005-2010 by Vietnam Women’s Union.
  • November 10, 2011: granted certificate of copyright “Medicine for hemorrhoids formulated from bioactive flavonoids extracted from Amaranthus spinosus L. and Portulaca oleracea L. in Vietnam by the Department of copyright.
  • January 20, 2012: awarded the National prize in science and technology entitled “Research work group on Vietnamese Crinum latifolium L.” by the President.
  • May 19, 2012: awarded Badge of 30 years as Party member by Central Committee of the Communist Party of Vietnam.

PUBLISHED ARTICLES AND PAPERS ON JOURNAL OF SCIENCES

Dr Tram Crila Inventor - Published papers

Tram NTN, Mitova M, Bankova V, Handjieva N, Popov SS.

  • GC-MS of Crinum latifolium L. alkaloids.
  • Z Naturforsch. 2002; 57c: 239-242.

Tram NTN, Zornitza G.Kamenarska, Nedyalka V.Handjieva, Vassya S.Bankova and Simeon S.Popov.

  • Volatiles from Crinum latifolium.
  • J.Essent. Oil Res., 2003, 15. 195-1973. 

Tram NTN, Titorenkova TV, St Bankova V, Handjieva NV, Popov SS.

  • Crinum L. (Amaryllidaceae).
  • Fitoterapia. 2002; 73: 183-208.
  • doi: 10.1016/S0367-326X(02)00068-04

Tram NTN, Zvetkova E, Nikolova E, Katzarova E, Kostov G, Yanchev I, Baicheva O.

  • A novel in vitro and in vivo T-lymphocyte activating factor in Crinum latifolium (L.) aqueous extracts.
  • Experimental Pathology and Parasitology. 1999; 3: 21-26.5.

Tram NTN, Yanchev I, Zvetkova E, Dineva J, Katzarova E, Kostov G, Svilenov D, Ilieva I, Shalamanov P.

  • Retarded growth of chemically induced with 20-methylcholanthrene tumours in rats under the action of cold-hot aqueous extracts (decoctions) from Vietnamese plant Crinum latifolium (L.)
  • Experimental Pathology and Parasitology. 2001; 4/7: 9-12.6. Zvetkova E, Wirleitner B, Tram NTN, Schennach H, Fuchs D.
  • Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells.
  • International Immunopharmacology. 2001; 1: 2143-2150.7.

Tram NTN, Zvetkova E, Nikolova E, Katzarova E, Arasheva M, Kostov G

  •  A novel in vitro and in vivo T-lymphocyte activating factor in Crinum latifolium (L.) hot aqueous extracts.
  • National Congress of Anatomy, Histology and Embryology with International Participation.
  • Pleven, 1999, 9, 17-198. Marcel Jenny, Angela Wondrak, Elizaveta Zvetkova, Nguyen Thi Ngoc Tram, Phan Thi Phi Phi, Harald Schennach, Zoran Culig, Florian Ueberall, Dietmar Fuchs.
  • Crinum Latifolium Leave Extracts Suppress Immune Activation Cascades in Peripheral Blood Mononuclear Cells and Proliferation of Prostate Tumor Cells.
  • Scientia pharmaceutica. 2011, 4, 1011-13.9. McKinney CS, Tram NTN.
  • Good Agriculture & Collection Practices for New vVariety Crinum latifolium L. var. Crilae

TRAM N.T.N. Enables the First Commercial Scale Production of this Vietnamese Traditional Medicinal Herb.

  • Journal of Medicinal Plant and Natural Product Research. 2012, 509.10. Tram NTN, E. Zvetkova, E. Nikolova, E. Katzarova, G. Kostov
  • A new activator of T-lymphocytes in vitro and in vivo of hot aqueous extract from Crinum latifolium L. leaves
  • Journal of Pharmacy 8/2000, 8-9.11. Tram NTN, Bao Loc
  • Survey of botany, cultivation and harvest of Crinum latifolium L.
  • Journal of Pharmacy 2/2001, 21-2212. Tram NTN, Z.Kamenarska, V.Bankova, S.Popov, E.Zvetkova, E.Katzarovo, Le Mai Huong
  • Cytotoxic activity of alkaloid fractions from Crinum latifolium L. Amaryllidaceae
  • Journal of Pharmacy 11/2001, 21-23.13. Tram NTN, Phan Thi Phi Phi, Phan Thi Thu Anh
  • The effect of CRILA capsules (Vietnamese Crinum latifolium L.) on the restoration of T-lymphocyte and myeloid line.
  • Journal of Pharmacy 5/2008, 10-14.14. Tram NTN, Vu Thi Ngoc Thanh, Tran Hung, Dao Van Phan
  • Selective research of effects of flavonoid extracted from Vietnamese Houttuynia cordata Thunb. on smooth muscle and  haemostasis.
  • Journal of Pharmacy 4/2011, 19-24.15. Tram NTN, Tran Cong Khanh
  • Crinum latifolium L. var. crilae Tram & Khanh, var. n.: A new variety of the species Crinum latifolium L. (Amaryllidaceae) in Vietnam
  • Journal of Biology, 2012, 34(2): 190-193